Fig. 7.1 The mechanism underlying NO-repressed autophagy. NO inhibits JNK1 phosphorylation by S-nitrosylation. Decrease of phospho-Bcl-2 and increase of Bcl-2-Beclin1 interaction disrupt Vps34-Beclin1 association. NO also inhibits IKKb phosphorylation by S-nitrosylation….
Group A415 A476 Control 24 h 0.044 ± 0.001 0.042 ± 0.004 ART 24 h 0.145 ± 0.002* 0.110 ± 0.003** ART 48 h 0.033 ± 0.001* 0.123 ± 0.002** ART 96 h 0.049 ± 0.002* 0.131 ± 0.002** ART artemisinin. The singular asterisk (*) represents statistically significant difference from…
Metabolites Pathways and genes Up/downregulation folds CR ART H2O2 Glucose Glycolysis Acs2 −17.28 −2.63 −3.02 Adh6 −6.18 −1.54 −3.06 Ald3 −1.49 −1.83 2.13 Eno1 −1.75 −1.38 −2.26 Pdc6 −4.88 −2.16…
Fig. 2.1 The isoprenoid biosynthesis pathway-based opening/closing carbon flux strategies aiming at ART overproduction in A. annua L. ABA abscisic acid; DMAPP dimethylallyl diphosphate; DXP deoxyxylulose 5-phosphate; DXR DXP reductoisomerase; DXS…
Fig. 4.1 Induction of NO production in B. licheniformis upon acclimatization to oxidative stress and suppression of oxidative stress-inducible NO. ART artemisinin; l–NMMA NG-monomethyl-l-arginine monoacetate; NO nitric oxide. Double asterisks (**)…
Fig. 1.1 The multifaceted beneficial effects exerted by ART through specifically targeting a variety of hemoproteins. ART artemisinin; bNOS bacterial nitric oxide synthase; COX cytochrome c oxidase; CR calorie restriction; NO…
Fig. 5.1 Dynamic monitoring of NO production and comparative analysis of relationship between NO and SpO2 in BIA, CIA and BIA-CIA mice. a Time course detection of serum NO levels in…
