Syringoma
Senait W. Dyson, MD
David Cassarino, MD, PhD
Key Facts
Terminology
Benign ductal proliferation in superficial dermis
Clinical Issues
Predilection for eyelids
Often multiple, small, skin-colored to translucent papules
More common in Down syndrome patients
More common in females
More common in Asians
Microscopic Pathology
Small ducts, nests, and cords in superficial dermis
Ducts lined by 1 or 2 layers of cuboidal cells
Tadpole-like pattern with comma-like tails
Fibrotic stroma
Top Differential Diagnoses
Desmoplastic trichoepithelioma
Microcystic adnexal carcinoma
Morpheaform basal cell carcinoma
 Multiple, small, skin-colored to white papules on the eyelids  are the classic presentation of a syringoma. |
 In the superficial dermis, a proliferation of ductal structures embedded in fibrotic stroma is seen. Some of the ducts have comma-like tails  . |
TERMINOLOGY
Definitions
Benign eccrine ductal proliferation in superficial dermis
ETIOLOGY/PATHOGENESIS
Etiology
Eruptive syringomas may be due to autoimmune destruction of acrosyringium
CLINICAL ISSUES
Epidemiology
Incidence
Relatively common tumors
Age
Puberty to old age
Gender
More common in females
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