Superficial Cervicovaginal Myofibroblastoma
Elizabeth A. Montgomery, MD
Key Facts
Clinical Issues
Adults; mean age about 60 years
Polypoid or nodular mass of vagina, cervix, or vulva
Treatment: Excision
Prognosis: Excellent; benign lesions
Microscopic Pathology
Uninvolved Grenz zone between lesion and overlying mucosa or skin
Moderately cellular
Bland ovoid to spindle or stellate cells
Some cells with wavy appearance
Multiple patterns possible
Lace-like, sieve-like, fascicular
Several patterns can be seen in same lesion
Finely collagenous stroma
Occasional mitotic figures
Desmin(+), ER(+), PR(+), CD34(+)
 Superficial cervicovaginal myofibroblastoma is characterized by a monotonous proliferation of bland ovoid, spindle, or stellate cells arranged in a monotonous pattern. |
 Note the bland appearance of the stellate cells in this image. The lesion is moderately cellular, and there is a background of delicate wavy collagen. Note the scattered background lymphocytes  . |
TERMINOLOGY
Synonyms
Myofibroblastoma of lower female genital tract
Definitions
Polypoid or nodular benign lesions of vagina, cervix, or vulva, composed of bland mesenchymal cells
CLINICAL ISSUES
Epidemiology
Age
Adults
Mean: About 60 years
Gender
Women
Presentation
Polypoid or nodular mass
Vagina, cervix, or vulva
Treatment
Excision
