Superficial Cervicovaginal Myofibroblastoma

Elizabeth A. Montgomery, MD

Key Facts

Clinical Issues

Adults; mean age about 60 years
Polypoid or nodular mass of vagina, cervix, or vulva
Treatment: Excision
Prognosis: Excellent; benign lesions

Microscopic Pathology

Uninvolved Grenz zone between lesion and overlying mucosa or skin
Moderately cellular
Bland ovoid to spindle or stellate cells
Some cells with wavy appearance
Multiple patterns possible
- Lace-like, sieve-like, fascicular
- Several patterns can be seen in same lesion
Finely collagenous stroma
Occasional mitotic figures
Desmin(+), ER(+), PR(+), CD34(+)

Superficial cervicovaginal myofibroblastoma is characterized by a monotonous proliferation of bland ovoid, spindle, or stellate cells arranged in a monotonous pattern.

Note the bland appearance of the stellate cells in this image. The lesion is moderately cellular, and there is a background of delicate wavy collagen. Note the scattered background lymphocytes