Staging for Specimens of Squamous Cell Carcinoma of Skin

 pN2a: Metastasis in single ipsilateral lymph node, > 3 cm to < 6 cm in greatest dimension


image pN2b: Metastasis in multiple ipsilateral lymph nodes, none > 6 cm in greatest dimension

image pN2c: Metastasis in bilateral or contralateral lymph nodes, none > 6 cm in greatest dimension


• pN3: Metastasis in a lymph node, > 6 cm in greatest dimension

• pMX: Not applicable or unknown (not necessary to report)

• pM1: Distant metastasis
image Specify site(s), if known




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Clinical Photograph of T1 Squamous Cell Carcinoma on Forehead
This is a small invasive squamous cell carcinoma (SCC) arising on the forehead of an adult female. The tumor is less than 2 cm in greatest dimension and did not have any high-grade features histologically, consistent with a T1 tumor.


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Histologic Section of Invasive, Well- to Moderately Differentiated SCC
This is an example of a small, superficially invasive, well- to moderately differentiated SCC (T1). Note the enlarged, hyperchromatic staining nuclei with focal spindling and scattered mitoses image.


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Squamous Cell Carcinoma In Situ (Tis)
Squamous carcinoma in situ (Bowen disease) shows growth limited to the epidermis (Tis).

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Superficially Invasive Squamous Cell Carcinoma (T1)
Invasive SCC shows superficial invasion into the dermis image. This is a tumor ≤ 2 cm in greatest dimension with < 2 high-risk features (T1).

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Deeply Invasive Squamous Cell Carcinoma (T2)
A tumor > 2 cm in greatest dimension ± 1 additional high-risk feature or any size with ≥ 2 high-risk features is staged as T2.

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PET/CT of Squamous Cell Carcinoma
Axial fused PET/CT scan shows an increase in size and metabolic activity of a left scalp mass image; excision confirmed an invasive SCC of > 2 cm in greatest dimension (T2).

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Apr 24, 2017 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Staging for Specimens of Squamous Cell Carcinoma of Skin
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