Staging for Specimens of Squamous Cell Carcinoma of Skin
pN2a: Metastasis in single ipsilateral lymph node, > 3 cm to < 6 cm in greatest dimension
pN2b: Metastasis in multiple ipsilateral lymph nodes, none > 6 cm in greatest dimension
pN2c: Metastasis in bilateral or contralateral lymph nodes, none > 6 cm in greatest dimension
• pN3: Metastasis in a lymph node, > 6 cm in greatest dimension
• pMX: Not applicable or unknown (not necessary to report)
• pM1: Distant metastasis
Specify site(s), if known
Clinical Photograph of T1 Squamous Cell Carcinoma on Forehead This is a small invasive squamous cell carcinoma (SCC) arising on the forehead of an adult female. The tumor is less than 2 cm in greatest dimension and did not have any high-grade features histologically, consistent with a T1 tumor.
Histologic Section of Invasive, Well- to Moderately Differentiated SCC This is an example of a small, superficially invasive, well- to moderately differentiated SCC (T1). Note the enlarged, hyperchromatic staining nuclei with focal spindling and scattered mitoses .
Squamous Cell Carcinoma In Situ (Tis) Squamous carcinoma in situ (Bowen disease) shows growth limited to the epidermis (Tis).
Superficially Invasive Squamous Cell Carcinoma (T1) Invasive SCC shows superficial invasion into the dermis . This is a tumor ≤ 2 cm in greatest dimension with < 2 high-risk features (T1).
Deeply Invasive Squamous Cell Carcinoma (T2) A tumor > 2 cm in greatest dimension ± 1 additional high-risk feature or any size with ≥ 2 high-risk features is staged as T2.
PET/CT of Squamous Cell Carcinoma Axial fused PET/CT scan shows an increase in size and metabolic activity of a left scalp mass ; excision confirmed an invasive SCC of > 2 cm in greatest dimension (T2).
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