pN2c: Satellite or in-transit metastasis without nodal metastases
• pN3: Metastasis in 4 or more regional lymph nodes, or matted lymph nodes, or in-transit or satellite metastases with positive regional nodes
• pM1 (required only if there is confirmed metastasis)
pM1a: Metastasis to skin, subcutaneous tissue, or distant lymph node(s)
pM1b: Metastasis to lung
pM1c: Metastasis to all other visceral sites or distant metastasis associated with elevated serum LDH levels
– Specify site:____
Melanoma In Situ (Tis) Tis melanoma is a melanoma in situ with no evidence of dermal invasion.
Metastatic Melanoma on PET/CT Scan Axial fused PET/CT in a patient with melanoma shows intense FDG activity in a lesion in the right posterior neck musculature, consistent with metastatic disease (M1a).
T1a Invasive Melanoma T1a invasive melanoma shows a tumor with superficial invasion ≤ 1.0 mm in thickness, without ulceration or evidence of dermal mitotic activity.
T1b Invasive Melanoma T1b invasive melanoma shows a tumor invasive ≤ 1.0 mm in thickness, with ulceration &/or evidence of dermal mitotic activity (≥ 1/mm²). T1b tumors are clinically more aggressive and have a higher incidence of metastasis than T1a tumors.
T2a Invasive Melanoma T2a melanoma invades to > 1.0 mm in thickness , but is ≤ 2.0 mm in depth, and lacks evidence of ulceration.
T2b Invasive Melanoma T2b melanoma invades to > 1.0 mm in thickness , but is ≤ 2.0 mm in depth, and shows evidence of ulceration . Ulceration is one of the worst prognostic findings.
T3a Invasive Melanoma T3a melanoma invades to > 2.0 mm in thickness, but is ≤ 4.0 mm in depth, and lacks evidence of ulceration.
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