Sebaceous Hyperplasia

 Sebocytes in lobules, rimmed by more than 1 layer of basaloid cells

image Often connecting directly to epidermal surface

• Ectopic sebaceous glands in other sites (e.g., nipple)
image Often connect directly to epidermal surface

• Phymatous rosacea
image Prominent sebaceous glands, edema, and fibrosis on different sites

image Clinical history is key

• Sebaceous trichofolliculoma
image Mature, central hair follicle, often producing hair shaft

image Smaller, baby hair follicles and sebaceous glands radiating away from central follicle

• Folliculosebaceous cystic hamartoma
image Central dilated infundibulum surrounded by hair follicles and sebaceous glands

image Fibrocytic stroma

• Sebaceous induction
image Lobules of sebocytes connecting to epidermal surface

image Most commonly seen above dermatofibroma

Sebaceous Hyperplasia
Low-magnification view of sebaceous hyperplasia. There are normal-appearing lobules of sebocytes surrounding invaginations of epidermis that resemble the infundibula of hair follicles image.

Sebaceous Hyperplasia Attached to Follicular Infundibulum
Lobules of sebocytes surround an invagination of epidermis image that resembles the infundibulum of a hair follicle. The lobules of sebocytes are rimmed by a single compressed layer of small basaloid cells image.

Sebaceous Hyperplasia at High Magnification
High-power view of sebocytes shows bubbly cytoplasm and a central round or scalloped image nucleus.

Sebaceous Hyperplasia at High Magnification
High-magnification view of the edge of a lobule of sebocytes shows the central sebocytes image with round to scalloped nuclei and bubbly cytoplasm, rimmed by a compressed layer of small, basaloid cells image.



• Hyperplasia (overgrowth) of sebaceous glands

• Plump lobules of sebaceous glands arranged around central follicular structures



• Commonly on face

• Rarely on trunk or other sites


• Yellow to flesh-colored to slightly pink papule

• Often there is central dell

• Telangiectasias may be present

• Often biopsied to rule out basal cell carcinoma

Laboratory Tests

• Generally not performed

• Some have suggested that sebaceous hyperplasia on sites other than face is sufficiently rare that evaluation for Muir-Torre syndrome is warranted; however, recent study of vulvar sebaceous hyperplasia showed no association with Muir-Torre syndrome


• Not necessary in most cases

• Biopsy (shave removal) may be curative

• Some studies suggest effective treatment with oral retinoids or lasers

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Apr 24, 2017 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Sebaceous Hyperplasia

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