Mucinous breast carcinoma
Mucinous colonic carcinoma
•
Other primary cutaneous tumors with mucin
Basal cell carcinoma
Adenoid cystic carcinoma
TERMINOLOGY
Abbreviations
•
Primary cutaneous mucinous carcinoma (PCMC)
Synonyms
•
Mucinous carcinoma, mucinous eccrine carcinoma, endocrine mucin producing carcinoma
Definitions
•
Malignant cutaneous tumor with classic histology of epithelial islands “floating” in pools of mucin
CLINICAL ISSUES
Epidemiology
•
Sex
Men affected more often than women
Presentation
•
Occurs in adults and elderly
•
Commonly on face, especially on eyelids
•
Slow-growing, asymptomatic, solitary reddish papule, nodule, or cyst
Treatment
•
Surgical approaches
Wide local excision, ± dissection of regional lymph nodes
Mohs micrographic surgery
Antiestrogen drugs have been tried for patients with ER-positive tumors
Chemotherapy and radiation have not been helpful in recurrent tumors
Prognosis
•
Up to 36% local recurrence and up to 15% metastasis to regional lymph nodes or distant metastasis
MACROSCOPIC
Size
•
0.5-7 cm; rare larger lesions
MICROSCOPIC
Histologic Features
•
Highly distinct low-power histologic appearance
Composed of epithelial cells in nests and cords present in large pools of mucin
•
Well-circumscribed, dermal-based tumor with occasional extension into subcutaneous tissues
•
Occasional overlying ulceration
•
Strands of fibrous tissue divide tumor into different compartments