Predisposition Factors of Type II Diabetes Mellitus and Related Complications


Ranking

Country

T II DM people

1

India

79.4

2

China

42.3

3

U.S.

30.3

4

Indonesia

21.3

5

Japan

13.9

6

Pakistan

11.3

7

Russia

11.1

8

Brazil

8.9

9

Italy

7.8

10

Bangladesh

6.7



This review describes global studies on of diabetes over years. Earliest study on prevalence of diabetes in India done by documentation record is in Kolkata in 1938 [5] followed by studies in 1959 in Mumbai [6]. More than 70 % of the population resides in rural area where studies revealed much higher prevalence that may be expected which started in early 70s. First ever Studies in rural areas of different parts of the country based on the WHO criteria were done on farmers following traditional life style and are dependent on agricultural economy [7]. The prevalence was higher among women above 50 years of age and that of men was irrespective of age. Prevalence of known diabetes was 6.1 % in all subjects aged 40 or over and rose to 13.3 % in the age group 50–59 years [8] as reported in door to door survey in 80s. Glucose intolerance is present 11.5 % of the rural South Indian population aged 40 years or over is the finding of 1994 study [9]. Very high levels of diabetes in comparison to rural population have been reported in urban areas of India [10] and other parts of the world in the age group 45–64 years and 65 years respectively. T II DM is designated as disease of elderly and middle aged but in recent years shift in the age of onset of diabetes is observed as major issue of worry in children as well as adolescents. The no of reports of children affecting from diabetes is increasing year by year day. Before 1990, there were only 2 reports; between 1990 and 1994, 4 reports; 1995–1999, 12 reports; and between 2000 and 2003, 53 reports and the number goes on increasing. A few of the findings are in the table below.



Children and adolescents affected with diabetes mellitus


































S. No.

Population

Area

Finding

References

1.

Adolescents and children

North America

Sixfold increase

[11]

2.

Adolescents

Greater Cincinnati

Obesity and strong family history

[12]

3.

Pima Indians

Arizona

Increased from 0.3 to 1.2/100,000/year before 1992 to 2.4/100,000/year in 1994

[13]


5.1.1 Predisposition Factors


Several controllable and non-controllable predisposition factors are responsible for identification of at-risk individuals to T II DM. These broadly classified into Environmental Predisposition, Biochemical Predisposition factors and Genetic Predisposition factors.


Environmental Predisposition Factors

Asian Indian people are more prone to diabetes than European descent people [10, 14]. Major environmental factors that contribute long-term complications associated with the of diabetes [15]. The highest rates of T II DM are found among Native Americans, particularly the Pima Indians who reside in Arizona in the US, and in natives of the South Pacific islands, such as Nauru [4]. There is high prevalence of T II DM among Europeans, Americans, Chinese, and Asian Indians. The variation is due to increased insulin resistance according to inter ethnic difference. A factor such as obesity, sedentary lifestyle, diet rich in animal products, and aging has attributed to tremendous increase in T II D Obesity is an established risk factor for T II DM [16].




Comparisons of characteristics of the three main race and ethnic groups





























S. No.

Population

Percentage affected (%)

Reference

1.

Hispanic Caucasians

74.4

[17]

2.

Non-hispanic African–African–Americans

15.0

[17]

3.

Mexican–Americans

5.8

[17]


5.1.2 Biochemical Predisposition Factors


Endothelial dysfunction (ED) is associated with the presence of atherosclerosis [18]. There is association of many novel biochemical Predisposition factors with incidence of diabetes. The poor glycaemic control, a longer duration of diabetes results in the complications of the Type II diabetes [19].


Genetic Predisposition Factors

Genetic predisposition to the disease is indicated by its characteristic feature to run in a family. Progress in gene identification for genomic DNA sequence variation more common responsible, multifactorial forms of T II DM has been slower may genes are identified and a large number of researchers have given lot of contribution for the study of Genetic Predisposition of T II DM. This review tries attempts to summarize work done by various researchers.














Gene

Year

Population affected

References

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Oct 21, 2016 | Posted by in BIOCHEMISTRY | Comments Off on Predisposition Factors of Type II Diabetes Mellitus and Related Complications

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