Paraganglioma-like Dermal Melanocytic Tumor



Paraganglioma-like Dermal Melanocytic Tumor


David Cassarino, MD, PhD

Cyril Fisher, MD, DSc, FRCPath










Histologic sections show a diffuse proliferation of clear cells located in the dermis. PLDMT is often a well-circumscribed, but unencapsulated, dermal-based tumor that can extend into the subcutis.






High magnification shows that the tumor is composed of closely packed nests of cells with clear or granular cytoplasm and round to oval nuclei with small nucleoli image.


TERMINOLOGY


Abbreviations



  • Paraganglioma-like dermal melanocytic tumor (PLDMT)


Definitions



  • Dermal-based low-grade melanocytic tumor with histologic similarities to paraganglioma


CLINICAL ISSUES


Epidemiology



  • Incidence



    • Very rare tumors; only 10 cases reported to date


  • Age



    • Typically occur in young adults



      • Range: 18-53 years


      • Mean: 35 years


  • Gender



    • More common in females


Site



  • Usually occur on extremities



    • Mostly lower limb



      • Thigh, knee, lower leg

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Jul 8, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Paraganglioma-like Dermal Melanocytic Tumor
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