Panfolliculoma

 Cystic areas resembling infundibulum with stratified squamous epithelium, granular layer, and basket-weave stratum corneum


image Areas resembling internal and external root sheath

image Foci of matrical epithelium

image Areas resembling hair bulb with papillary mesenchymal bodies





Top Differential Diagnoses




• Trichoblastoma
image Less organized

image Lacks more advanced follicular differentiation

image Lacks areas resembling infundibulum

image Usually composed entirely of basaloid epithelium

• Trichoepithelioma
image Less organized

image Also lacks more advanced follicular differentiation

image Lacks areas resembling infundibulum

image Usually composed entirely of basaloid epithelium

• Pilomatrixoma
image Less organized

image Consists only of matrical epithelium and ghost cells

image Lacks papillary mesenchymal bodies

image Lacks areas resembling infundibulum

image Frequent associated granulomatous inflammation

• Trichofolliculoma
image Multiple secondary follicles connecting to large, central, cystically dilated follicular structure

image Sebaceous glands often present

image Panfolliculoma lacks central cystic structure

image Sebaceous glands absent in panfolliculoma

image
Low-Power Image of Panfolliculoma
Panfolliculoma is characterized by a dermal-based adnexal proliferation recapitulating all levels of the hair follicle.


image
Medium-Power Image of Panfolliculoma Resembling Primitive Follicles
Panfolliculoma shows cystic areas lined by stratified squamous epithelium with a granular layer image, basaloid epithelium with papillary mesenchymal bodies image, and inner and outer root sheath image.

image
Higher Power Image of Panfolliculoma With Component Resembling Infundibulum
The cystic areas are lined by stratified squamous epithelium with a granular layer and filled with abundant laminated keratin image, consistent with infundibular differentiation.

image
High-Power Image of Panfolliculoma With Hair Bulb Formation
There is advanced follicular differentiation with external image and internal image root sheath formation, as well as matrical image epithelium. At the base there is a condensation of spindled cells representing a papillary mesenchymal body image.

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Apr 24, 2017 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Panfolliculoma

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