Panfolliculoma

 Cystic areas resembling infundibulum with stratified squamous epithelium, granular layer, and basket-weave stratum corneum

image Areas resembling internal and external root sheath
image Foci of matrical epithelium
image Areas resembling hair bulb with papillary mesenchymal bodies

Top Differential Diagnoses

• Trichoblastoma
image Less organized
image Lacks more advanced follicular differentiation
image Lacks areas resembling infundibulum
image Usually composed entirely of basaloid epithelium
• Trichoepithelioma
image Less organized
image Also lacks more advanced follicular differentiation
image Lacks areas resembling infundibulum
image Usually composed entirely of basaloid epithelium
• Pilomatrixoma
image Less organized
image Consists only of matrical epithelium and ghost cells
image Lacks papillary mesenchymal bodies
image Lacks areas resembling infundibulum
image Frequent associated granulomatous inflammation
• Trichofolliculoma
image Multiple secondary follicles connecting to large, central, cystically dilated follicular structure
image Sebaceous glands often present
image Panfolliculoma lacks central cystic structure
image Sebaceous glands absent in panfolliculoma
image
Low-Power Image of PanfolliculomaPanfolliculoma is characterized by a dermal-based adnexal proliferation recapitulating all levels of the hair follicle.

image
Medium-Power Image of Panfolliculoma Resembling Primitive FolliclesPanfolliculoma shows cystic areas lined by stratified squamous epithelium with a granular layer image, basaloid epithelium with papillary mesenchymal bodies image, and inner and outer root sheath image.
image
Higher Power Image of Panfolliculoma With Component Resembling InfundibulumThe cystic areas are lined by stratified squamous epithelium with a granular layer and filled with abundant laminated keratin image, consistent with infundibular differentiation.
image
High-Power Image of Panfolliculoma With Hair Bulb FormationThere is advanced follicular differentiation with external image and internal image root sheath formation, as well as matrical image epithelium. At the base there is a condensation of spindled cells representing a papillary mesenchymal body image.

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Apr 24, 2017 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Panfolliculoma

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