Palisaded Myofibroblastoma
Cyril Fisher, MD, DSc, FRCPath
Key Facts
Terminology
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Benign spindle cell tumor of modified smooth muscle cells in lymph node
Clinical Issues
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Mainly inguinal region
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Mostly in males
Macroscopic Features
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Cut surface often dark red or black
Microscopic Pathology
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Rim of lymph node tissue
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Focal palisading, amianthoid fibers
Ancillary Tests
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Actin(+), desmin(-), and CD34(-)
Top Differential Diagnoses
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Kaposi sarcoma
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Schwannoma
Gross pathology photograph shows a hemorrhagic tumor extensively replacing the lymph node. Residual nodal tissue is seen at the periphery  . |
Hematoxylin & eosin shows a cellular tumor with irregular fascicles and vague palisades of uniform spindle cells. Note rim of compressed lymph node  . |
TERMINOLOGY
Synonyms
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Intranodal hemorrhagic spindle cell tumor with amianthoid fibers
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Solitary spindle cell tumor with myoid differentiation of lymph node
Definitions
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Benign spindle cell tumor of modified smooth muscle cells in lymph node
CLINICAL ISSUES
Epidemiology
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Incidence
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Rare
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Mainly inguinal region
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Occasionally in submandibular lymph node
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Rarely multicentric
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Age
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5th and 6th decades
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Gender
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