Small, Nevoid Appearance Nevoid melanoma is deceptively symmetrical, mimicking an intradermal nevus on low-power examination. The only clue is hypercellularity (blue appearance) and lack of maturation, which should invoke a closer scrutiny.
TERMINOLOGY
Synonyms
• Some cases have been described as “minimal deviation melanoma,” but this term is very controversial and should be avoided
Definitions
• Uncommon variant of melanoma that shows histological features mimicking a nevus
ETIOLOGY/PATHOGENESIS
Environmental Exposure
• Likely solar/UV radiation related, similar to most types of melanoma
CLINICAL ISSUES
Presentation
• Occurs in wide age range
• Can be ubiquitous, but occurs more frequently on back and extremities
• Dome-shaped papule or nodule or verrucous lesion
• Often not recognized clinically as melanoma
Can resemble nevus or basal cell carcinoma
Treatment
• Surgical approaches
Complete excision with clear margins
Sentinel lymph node biopsy often performed for staging, especially if lesion is thicker than 1.0 mm or
– Level IV
– Ulcerated
– Exhibits dermal mitotic figures
Prognosis
• Similar to conventional melanoma
• Determined by AJCC staging, especially depth of invasion (Breslow depth), ulceration, and mitotic activity
MICROSCOPIC
Histologic Features
• At scanning magnification, there are 2 variants
Verrucous or papillated
– Mimics polypoid intradermal melanocytic nevus
Flat or dome-shaped
– Mimics ordinary intradermal or compound melanocytic nevus
• Imparts nevoid appearance on initial examination
Cells mimic type A nevus cells
Can also mimic lymphocytes
• Tightly packed, it forms sheets of relatively banal-appearing nevoid cells
Hypercellular
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