Solitary circumscribed neuroma (“palisaded encapsulated neuroma”) represents spontaneous proliferation of peripheral nerve fibers

Multiple mucosal neuromas associated with multiple endocrine neoplasia syndrome (type 2B) represent rare autosomal dominant condition

Traumatic neuroma represents post-traumatic proliferation of peripheral nerve fibers

Morton neuroma represents degenerative neural change with reactive fibrosis on the foot

Pacinian neuroma represents painful hyperplasia of pacinian bodies on finger

Epithelial sheath neuroma represents proliferation of enlarged dermal nerves ensheathed by squamous epithelium

Represents rare autosomal dominant condition

Also includes medullary carcinoma of thyroid, pheochromocytoma, and somatic abnormalities

Mucosal neuromas have been rarely reported without any other systemic features of the syndrome

Amputation neuroma represents painful, reactive proliferation of nerve fibers after amputation

Supernumerary digit represents proliferation of nonencapsulated nerve fibers after intrauterine or perinatal amputation of supernumerary digits

Lesion on penis may occur after circumcision

Degenerative damage of peripheral nerves

Solitary circumscribed neuroma is most common in 5th and 7th decades

Solitary circumscribed neuroma occurs in equal ratio in both genders

Majority (90%) located on face

Rare in other anatomic locations

Mucosal involvement has been reported rarely

Usually in distal parts of peripheral nerves of 3rd and 4th os metatarsale

Usually on fingers

Simple excision is curative