Neonatal Hemochromatosis



Neonatal Hemochromatosis


Matthew M. Yeh, MD, PhD









A case of neonatal hemochromatosis shows lobular necrosis and collapse of the hepatocellular cords with residual hepatocytes and bile ductules image.






Perl iron stain shows marked iron deposition image within the hepatocytes.


TERMINOLOGY



Synonyms



  • Congenital hemochromatosis


  • Neonatal iron storage disease



ETIOLOGY/PATHOGENESIS


Alloimmune Liver Injury



  • Transplacental transfer of maternal IgG leads to complement-mediated attack on fetal hepatocytes; antigen is still unknown

Jul 8, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Neonatal Hemochromatosis
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