Multicystic Peritoneal Mesothelioma
Cyril Fisher, MD, DSc, FRCPath
Key Facts
Terminology
Benign intraabdominal or pelvic lesion of parietal or serosal peritoneal mesothelium
Etiology/Pathogenesis
Minimal association with previous exposure to asbestos
Previous abdominal or pelvic surgery
Endometriosis
Adenomatoid tumor in ovary and other sites
Clinical Issues
More common in females
Incidental finding
Small number recur or spread
Microscopic Pathology
Cysts are lined by cuboidal or flattened epithelium
No cytological atypia
Mesothelial cell nests or pseudoglandular spaces in stroma of septa
 Hematoxylin & eosin shows multiple large cysts separated by connective tissue septa. Cysts vary in size and contain proteinaceous secretion. Note that the cyst lining lacks tufting or papilla formation. |
 Hematoxylin & eosin shows that the cyst is lined by a single layer of flattened or cuboidal cells  . Hobnail pattern, tufts, or papillae are sometimes seen. The septa are composed of vascular fibrous tissue. |
TERMINOLOGY
Abbreviations
Multicystic peritoneal mesothelioma (MPM)
Synonyms
Benign cystic mesothelioma
Peritoneal inclusion cyst
Definitions
Benign intraabdominal or pelvic lesion of parietal or serosal peritoneal mesothelium
Can be multicystic or composed of several separate cystic lesions
ETIOLOGY/PATHOGENESIS
Developmental Anomaly
Very rare familial cases described
Environmental Exposure
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