Leiomyomatosis Peritonealis Disseminata
Cyril Fisher, MD, DSc, FRCPath
Key Facts
Etiology/Pathogenesis
Associated with
Pregnancy
Hormonal therapy
Hormone-secreting tumors
Clinical Issues
Females
Fertile period
Especially in 4th decade
Throughout abdomen and pelvis
Microscopic Pathology
Subperitoneal nodules
Mature smooth muscle or myofibroblastic cells
No atypia or necrosis
Ancillary Tests
Smooth muscle: SMA, desmin, H-caldesmon, ER, and PR positive
 Hematoxylin & eosin shows ill-defined, variably sized nodules of spindled or ovoid cells  in a sparsely cellular fibrous stroma. Note relationship to peritoneal surface  . |
 Hematoxylin & eosin shows smooth muscle bundles in transverse section with epithelioid-like cellular morphology  . |
TERMINOLOGY
Abbreviations
Leiomyomatosis peritonealis disseminata (LPD)
Definitions
Multiple smooth muscle-like deposits
In abdomen or pelvis
Beneath peritoneal surfaces
ETIOLOGY/PATHOGENESIS
Associated with
