Intravascular Leiomyomatosis



Intravascular Leiomyomatosis


Elizabeth A. Montgomery, MD









Hematoxylin & eosin from a hysterectomy specimen shows intravascular growth of the lesion, which is more cellular than the investing vessels.






Hematoxylin & eosin shows the intravascular process at high magnification. Note the delicate longitudinal striations of the spindle cells image.


TERMINOLOGY


Synonyms



  • Intravenous leiomyomatosis


Definitions



  • Rare condition featuring growth of nodules of benign smooth muscle in veins of myometrium, some with extension into extrauterine veins


CLINICAL ISSUES


Presentation



  • Not applicable


  • Usually premenopausal women



    • Median age: Early 40s


  • Abnormal vaginal bleeding


  • Pelvic pain


  • Enlarged uterus


  • Some patients (10-20%) have tumor extending into vena cava or heart



    • Present with cardiac symptoms


Prognosis

Jul 9, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Intravascular Leiomyomatosis

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