Hibernoma



Hibernoma


Khin Thway, BSc, MBBS, FRCPath










Low-power histologic view shows hibernoma, which is composed of well-defined lobules of polygonal cells. Bland cells with the appearance of brown fat are mixed with mature adipocytes. No atypia is present.






Hibernoma is shown at higher magnification, comprising an admixture of polygonal cells with granular eosinophilic or multivacuolated cytoplasm. Univacuolated adipocytes are also seen.


TERMINOLOGY


Synonyms



  • Fetal lipoma, lipoma of embryonic fat


Definitions



  • Benign tumor most frequently occurring in younger adults, with differentiation toward brown fat



    • Tumor has characteristic cytogenetic aberrations, mainly involving 11q13-21


ETIOLOGY/PATHOGENESIS


Developmental Anomaly



  • Etiology unknown



    • Many occur at sites of normal brown fat in fetuses and newborns


    • Genetic changes in some


CLINICAL ISSUES


Epidemiology



  • Incidence



    • Rare; approximately 1% of all adipocytic tumors


  • Age



    • Peak incidence: 3rd decade


    • Rare in children


  • Gender



    • M = F

Jul 8, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Hibernoma
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