Ganglioneuroma



Ganglioneuroma


Khin Thway, BSc, MBBS, FRCPath









Needle core biopsy specimen of ganglioneuroma shows small numbers of mature ganglion cells singly image and in clusters, within a moderately cellular schwannian stroma-rich background.






The number of ganglion cells varies in this case of ganglioneuroma. They are numerous and mature with abundant cytoplasm. The stroma is composed of bland, Schwann cell-like spindle cells.


TERMINOLOGY


Abbreviations



  • Ganglioneuroma (GN)


Definitions



  • Benign, well-differentiated tumor of neural crest origin


  • Arises from sympathetic or peripheral nerves


ETIOLOGY/PATHOGENESIS


Associated Conditions



  • Within intestinal tract, lesions often associated with tumor syndromes



    • Polypoid GN in GI tract has associations with Cowden syndrome, juvenile polyposis, and tuberous sclerosis


    • Ganglioneuromatous polyposis reported in patients with neurofibromatosis type 1 and MEN2B


  • Most develop de novo



    • Some develop from maturation of neuroblastoma


CLINICAL ISSUES


Epidemiology

Jul 9, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Ganglioneuroma
Premium Wordpress Themes by UFO Themes
%d bloggers like this: