Fibrolipomatous Hamartoma



Fibrolipomatous Hamartoma


Cyril Fisher, MD, DSc, FRCPath









MR of the wrist shows abnormal fat signal image in the stroma between the nerve fascicles (black dots) of an enlarged median nerve.






Hematoxylin & eosin shows accumulation of mature adipose tissue with hypocellular fibrous septa around and between nerve bundles.


TERMINOLOGY


Synonyms



  • Fibrolipomatous hamartoma of nerve


  • Lipofibromatous hamartoma of nerve


  • Neural fibrolipoma


  • Neurolipomatosis, lipomatosis of nerve


Definitions



  • Increased fibrofatty tissue infiltrating and surrounding nerves


CLINICAL ISSUES


Epidemiology



  • Age



    • Predominantly in children, including congenital lesions


    • Some cases in young adults up to 30 years of age


    • Rarely in older adults


Site



  • Affects palmar surface of hand, wrist, forearm


  • Median nerve and branches most commonly affected


  • Rarely involves ulnar or radial nerve


  • Involves left arm more often than right arm


  • Very rarely involves sciatic, peroneal, or cranial nerve

Jul 9, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Fibrolipomatous Hamartoma
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