Ependymoma



Ependymoma


Elizabeth A. Montgomery, MD









Extraspinal ependymoma appears identical to those lesions arising in the neuraxis (4th ventricle, spinal cord central canal). Note the prominent vascularity at low magnification.






At high magnification, ependymomas are composed of cells with round nuclei and indistinct but fibrillary cytoplasm. Nucleoli are inconspicuous.


TERMINOLOGY


Synonyms



  • Extraspinal ependymoma, sacrococcygeal ependymoma


Definitions



  • Cellular glial or epithelial-appearing neoplasm manifesting ependymal differentiation as either perivascular rosettes or true rosettes



    • Myxopapillary variant has pseudopapillary architecture and intercellular myxoid matrix


ETIOLOGY/PATHOGENESIS


Subcutaneous Sacrococcygeal Ependymomas



  • Believed to arise from coccygeal medullary vestige



    • Ependymal-lined cavity composed of remnant of caudal portion of neural tube


Presacral Ependymomas



  • Believed to arise from extradural remnants of filum terminale


Ependymomas of Ovary and Mediastinum



  • Germ cell origin postulated


CLINICAL ISSUES


Epidemiology

Jul 9, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Ependymoma
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