Diseases and Conditions of the Respiratory System



Diseases and Conditions of the Respiratory System



Learning Objectives


After studying Chapter 9, you should be able to:


1. Explain the process of respiration.


2. Discuss the causes and medical treatment for (a) the common cold, (b) sinusitis, and (c) pharyngitis.


3. Name the treatment of choice for nasal polyps.


4. Discuss the prognosis of cancer of the larynx.


5. Define atelectasis and discuss some possible causes.


6. Name some systemic disorders that might cause epistaxis.


7. Compare the clinical pictures of (a) a patient with pulmonary embolism and (b) one with pneumonia.


8. List some possible causes of pulmonary abscess.


9. Compare legionellosis with Pontiac fever.


10. Explain who is at greatest risk for (a) respiratory syncytial virus pneumonia and (b) histoplasmosis.


11. List the groups recommended to receive prophylactic use of influenza vaccines.


12. Contrast the pathologic course of acute bronchitis with that of chronic bronchitis.


13. Compare the pathology involved in bronchiectasis with that of pulmonary emphysema.


14. Name and describe three causes of pneumoconiosis.


15. Explain the difference between pneumothorax and hemothorax.


16. Describe the presenting symptoms of pleurisy.


17. Discuss contributing factors to, and concern about, the rising prevalence of pulmonary tuberculosis.


18. Describe the clinical course of infectious mononucleosis.


19. Explain the pathologic changes of the lungs in adult respiratory distress syndrome (ARDS).


20. Name the leading cause of cancer deaths worldwide for both men and women.


21. Explain what determines the prognosis of sarcoidosis.


22. List some health hazards of common molds.




Orderly Function of the Respiratory System


The primary function of the pulmonary system is ventilation and respiration (Figure 9-1). Respiration maintains life by supplying oxygen to organs, tissues, and cells and allowing for the removal of carbon dioxide (a waste product of metabolism). This process is made possible by ventilation (the bellowslike action of the chest) and healthy lung tissue that is adequately perfused with blood. Breathing is controlled by the central nervous system; nerve stimulation of breathing begins in the medulla oblongata and pons. Pulmonary circulation is composed of pulmonary arteries that carry deoxygenated venous blood from the heart to the lungs; pulmonary capillaries in which gas exchange occurs; and pulmonary veins, which return the freshly oxygenated blood to the heart for systemic circulation. Lung tissue itself is supplied with oxygen and nutrients by the blood supply that is carried to it by the bronchial arteries.



The lungs, along with the kidneys, have a major metabolic function: the maintenance of acid-base (pH) balance of the blood. Lack of oxygen with hypercapnia (increased carbon dioxide in the blood) causes respiratory acidosis; hyperventilation may produce hypocapnia (a decreased amount of carbon dioxide in the blood), causing respiratory alkalosis. In both conditions, arterial blood gases are abnormal. The kidneys work to adjust bicarbonate in the blood in response to carbon dioxide.


In the lungs, oxygen inhaled from the air is exchanged with carbon dioxide from the blood; this process is called external respiration. Internal respiration refers to the exchange of gases between the blood and tissue cells. Carbon dioxide then is exhaled as a waste product. Inhaled and exhaled air passes through the respiratory tract, which includes the nose, pharynx, larynx, and trachea (Figure 9-2). E9-1



In the chest, the trachea bifurcates into the bronchi. Each bronchus enters a lung, where it further divides into increasingly smaller air passages called bronchioles. At the end of each bronchiole is a saclike cavity called an alveolus. There are approximately 300 million alveoli in each lung. The vital exchange of carbon dioxide for oxygen takes place through capillaries that lie next to the walls of the alveolus.


A muscular, dome-shaped partition called the diaphragm attaches to the lower ribs and separates the thoracic cavity from the abdominal cavity. On inspiration, the diaphragm contracts, pulling downward and causing air to be sucked into the lungs. During expiration, the diaphragm relaxes, pushing upward and forcing air out of the lungs (Figure 9-3). The expansion of the chest cavity, along with diaphragmatic contraction, is an active, energy-requiring process. Exhalation occurs as the stretched chest cavity springs back to its resting state along with the relaxation of the diaphragm. This is a passive process.



The membrane called the visceral pleura encases the lungs, and the parietal pleura lines the inside of the chest or thoracic cavity. The potential space between the visceral and parietal pleura is called the pleural cavity. Approximately 5 to 6 ml of pleural fluid is contained in the space between the pleurae, preventing friction and allowing the pleurae to slide easily on each other. Between the lungs is the mediastinum, where the heart, great vessels, trachea, esophagus, and lymph nodes are located.


Respiratory failure can be caused by the inability to ventilate, which results in an increasing buildup of carbon dioxide. Additionally, respiratory failure can result from the impairment of alveolar-arterial gas exchange, which results in a decrease of oxygen in the blood. Diseases of the respiratory system result from infection, circulatory disorders, tumors, trauma, immune diseases, congenital defects, central nervous system damage or diseases, inflammatory disturbances, or environmental conditions.


Chief symptoms indicating respiratory tract disorders that should receive medical attention include:




Common Cold/Upper Respiratory Tract Infection






Symptoms and Signs

Although the common, or “head,” cold is confined to the nose and pharynx, the same viruses can infect the larynx (see “Laryngitis” section) and various areas of the lungs (see “Acute and Chronic Bronchitis” section). The suffix “-itis” is added to the anatomical location where most of the inflammation is occurring (i.e., pharyngitis, laryngitis, tracheitis, or bronchitis). The symptoms of a cold tend to be subjective, and to some extent, depend on which virus is responsible; they include nasal congestion and discharge, sneezing, watering eyes, sore throat, hoarseness of the voice, and coughing. When this highly contagious inflammatory process first begins, the nasal discharge is usually clear and thin. In the adult, the symptoms usually abate in 5 to 7 days and without antibiotic therapy. In some cases the cold progresses and the discharge becomes greenish yellow and thick. Headache, a slight fever, and chills often accompany a cold. A high fever and malaise, however, are more likely to be symptoms of influenza (see “Influenza” section).






Treatment

An ordinary cold should clear up in 4 or 5 days, and a bacterial infection should resolve in no longer than a week to 10 days. Persistent cough or nasal congestion may suggest the presence of another process, such as allergies or asthma. There is no cure for a cold. Resting, drinking plenty of fluids, using a vaporizer, and taking over-the-counter antihistamines, decongestants, cough suppressants and mild analgesics can give temporary relief of symptoms. Note: Aspirin is contraindicated for infants and children; acetaminophen is the drug of choice.


The benefit to be gained from taking oral antihistamines to treat a cold is controversial. Antibiotics are of little value in treating viral infections; however, patients with recurring attacks of bronchitis (see “Acute and Chronic Bronchitis” section) or frequent middle ear infections may receive some protection against these bacteria-caused complications by taking antibiotics. There is some data to suggest that taking zinc lozenges may shorten (slightly) the course of the common cold.






Sinusitis






Symptoms and Signs

The sinuses, cavities behind the facial bones that shape the nose, cheeks, and eye sockets, are normally air filled. In sinusitis, the frontal sinuses (located in the forehead above the eyes) and the maxillary sinuses (located under the maxillary bones in the face) are the most commonly involved sinuses (Figure 9-4). When the frontal sinuses are affected, a headache is common over one or both eyes, especially upon waking in the morning. Pain and tenderness, felt just above the eyes and that usually intensifies when bending over, are also common symptoms. Pain in the cheeks and upper teeth is a symptom of sinusitis in the maxillary sinuses. Drainage, if present, will be a thick and greenish yellow mucopurulent discharge. The course of acute sinusitis is 3 to 4 weeks.







Treatment

Treatment of sinusitis can include saline nasal spray, corticosteroid nasal sprays, broad-spectrum antibiotics, oral corticosteroids, antihistamines, and decongestants. Decongestants alleviate symptoms by shrinking the swollen mucous membranes and drying up the nasal discharge. This expands the airway and eases breathing. Oral and topical corticosteroids decrease the inflammation of the affected area and decrease the sensitivity to aggravating stimuli. Oral antibiotics are used in the presence of bacterial infection and may include amoxicillin, doxycycline, sulfamethoxazole-trimethoprim, or cephalosporins. Other antibiotics may be used depending on the infecting organism. Determination of allergic sinusitis may include allergy testing followed by appropriate desensitization with immunotherapy and corticosteroids. If the inflammation persists, a minor surgery called sinusotomy may be advised by the physician. With the patient under local anesthesia, the physician pierces the maxillary sinus, allowing drainage and relief of pressure. Often the physician instills sterile water into the sinus to flush out any residual material. Analgesics usually are given for pain relief.






Pharyngitis








Etiology

The most common cause of pharyngitis is a viral infection; tonsillitis is the most important cause. In children, it is often an extension of a bacterial streptococcal infection from the tonsils, adenoids, nose, or sinuses. Persistent infection, or chronic pharyngitis, occurs when an infection (respiratory, sinus, or oral disease) spreads to the pharynx and remains. Acute pharyngitis may be secondary to systemic viral infections, such as chickenpox and measles, whereas chronic pharyngitis may accompany diseases, such as syphilis and tuberculosis. Gonococcal pharyngitis may result from oral-genital sexual activity with an infected partner. Pharyngitis also can be caused by irritation and inflammation without infection. Occasionally, inhalation or swallowing of irritating substances, such as tobacco smoke and alcohol, is responsible for trauma to the mucous membranes of the pharynx; breathing in excessively heated air or chemical irritants and swallowing sharp objects (e.g., a large ice chip or hard candy) also can cause trauma. Seasonal allergies may induce pharyngitis.







Patient Teaching

Instruct the patient to take the entire course of antibiotic therapy and keep follow-up appointments to ensure a cure and help prevent complications. Provide a list of comfort measures, such as safe use of analgesics, warm saline gargles, adequate fluid intake, and a soft diet. Advise patients with chronic pharyngitis to stop smoking; refer them to a support group.


Note: A more serious condition may appear initially as a routine pharyngitis. Ludwig’s angina involves a cellulitis on the floor of the mouth, whereas epiglottitis involves an infection of the structure overlying the voice box (larynx). Both are often characterized by fever and severe sore throat. However, drooling and difficulty breathing may occur and indicate some compromise to the respiratory tract. Patients should seek emergent medical attention if these symptoms develop.



Nasopharyngeal Carcinoma














Laryngitis








Etiology

The cause of laryngitis can be either viral or bacterial infection, and the condition can be either chronic or acute. URIs such as the common cold, tonsillitis, pharyngitis, and sinusitis are the most common causes of inflammation of the larynx. Laryngitis also occurs with bronchitis, pertussis, influenza, pneumonia, measles, mononucleosis, diphtheria, syphilis, and tuberculosis. Occasionally, laryngitis is caused by irritation without infection. Reflux laryngitis may result from repeated attacks of acid reflux. Inclement weather, tobacco smoke, drinking alcohol, inhalation of irritating materials, and excessive use of the voice are all predisposing factors, especially in the case of chronic laryngitis. Hoarseness can also be caused by benign or malignant lesions of the larynx. In most cases the pathology is benign, but malignancy must be ruled out.








Deviated Septum














Nasal Polyps














Anosmia














Epistaxis (Nosebleed)








Etiology

Common causes of epistaxis are colds and infections, such as rhinitis, sinusitis, and nasopharyngitis, which can cause crusting that damages the mucous membrane lining the nose or causes the rupture of tiny vessels in the anterior septum of the nose. Direct trauma to the nose, picking the nose, and the presence of a foreign body are the most common causes of epistaxis. Nasal hemorrhage also has been encountered in relation to many systemic disorders, such as measles, scarlet fever, pertussis, rheumatic fever, hypertension, congestive heart failure, and chronic renal disease. Epistaxis may be the foremost symptom of conditions, such as hemophilia, thrombocytopenia, agranulocytosis, and leukemia. Risk factors include vitamin K deficiency, hypertension, aspirin ingestion, high altitude, and anticoagulant therapy. An infrequent cause of epistaxis is extensive hepatic disease.








Tumors of the Larynx






Symptoms and Signs

Dysphonia is usually the only symptom of a tumor on the larynx. No influenza-like symptoms occur as with laryngitis (see “Laryngitis” section), but when the tumor is malignant, dysphagia may be experienced. In children with tumors, a high-pitched crowing sound called stridor is present because of their small airways. Hoarseness caused by a benign tumor is usually intermittent, whereas hoarseness caused by cancer is continuous and gradually becomes worse. Neither type of laryngeal tumor is common, but malignant tumors are slightly more common in men than women.




Etiology

There are two types of benign tumors: papillomas, which usually appear as multiples, and polyps, which usually appear singly (Figure 9-7). These tumors are caused by misuse or overuse of the vocal cords, although smoking and reflux are contributing factors. Malignant tumors occur more often in those who indulge in heavy tobacco use.


image
FIGURE 9–7 Vocal cord polyp.







Laryngeal Cancer









Diagnosis

Laryngeal cancer is often diagnosed at an earlier stage than other head and neck cancers because hoarseness usually occurs early in the disease process. Flexible fiberoptic endoscopy allows visualization of the larynx and assessment of vocal cord mobility. Diagnosis of cancer requires a biopsy, which is usually done by fine-needle aspiration. Staging is done using a TNM (Tumor, Node, Metastasis) system. A computed tomography (CT) scan or magnetic resonance imaging (MRI) scan is performed to evaluate depth and extent of tumor invasion and to look for nodal metastasis. A panendoscopy (laryngoscopy, esophagoscopy, and bronchoscopy) is generally done as well to look for other areas of tumor growth because tobacco and alcohol use often have widespread toxic effects on the aerodigestive tract. A PET scan can be done to look for distant metastases.



Treatment

The larynx plays an important role in speech, swallowing, respiration, and protection of the lower airway. Therefore, quality of life issues are often incorporated into the treatment plan. For early stage cancer, often the physician will explain the risks and benefits of surgery and radiation therapy, both of which have a similar outcome, and let the patient decide on the therapy. Usually the patient will choose the option that preserves voice—radiation. Surgical options include partial laryngectomy, total laryngectomy, and endoscopic laser resection. The choice largely depends on tumor stage. Treatment of later stage (III and IV) cancers is more difficult. For patients with resectable tumors, treatment usually consists of surgery followed by radiation therapy or by radiation alone. Chemoradiotherapy may be tried in patients choosing an organ-sparing approach. For patients who do undergo a laryngectomy, follow-up care generally requires the services of a speech therapist for speech therapy and swallowing therapy.






Hemoptysis


Apr 4, 2017 | Posted by in GENERAL & FAMILY MEDICINE | Comments Off on Diseases and Conditions of the Respiratory System

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