Given the above-mentioned beneficial effects of LB on human skin, we searched and failed to locate any publications pertaining to the effect—whether positive or negative—of this medicinal plant on wound healing. Therefore, we conducted a 3-day study on a partial thickness wound model in FT (full thickness) skin substitutes (MatTek, Ashland, MA), where the epidermal layer is peeled off and the underlying dermal layer is exposed. The histochemical Masson trichrome stain at day 3 (Fig. 5.2) shows that compared to the untreated control, the LBP-treated wounds present a more advanced stage of healing. The difference with controls consists in fibroblasts (dark purple stain), which appear to migrate upward providing topical coverage of the wound, while increasing the collagen output (the blue stain) to facilitate this migration (Sunny BioDiscovery, Inc. unpublished results). This is in agreement with the other two reports of the stimulatory effect of LBP on human dermal fibroblasts (Zhao et al. 2005; Wang et al. 2011) and with the general understanding of the role of the directional migration of fibroblasts during wound healing (Song et al. 2013). However, there is no straight path to LBP-based wound dressings. This is because LB peptidoglycans were reported to potentiate the effect of warfarin—a blood thinner, raising concerns about the adverse effects on blood coagulation (Lam et al. 2001; Ge et al. 2014). Interestingly, both coagulants and anticoagulants have been reported to stimulate wound healing (Carney et al. 1992; Fan et al. 2014) and whether LB interferes with this process in the absence of warfarin, as well as the utility of LB in wound dressings remain to be discovered.