Dermal Papule Dermal nerve sheath myxoma typically presents as a firm papule that varies from 0.5-4.5 cm in size. It usually occurs in adults. Common locations are the finger, hand, and pretibial skin.
Dermal Nerve Sheath Myxoma Dermal nerve sheath myxoma has a very distinctive architecture, consisting of well-defined myxoid lobules. It is typically centered within the dermis and can involve the underlying subcutis as well.
Composed of Schwann Cells The cells in dermal nerve sheath myxoma have schwannian differentiation. They have uniform spindle-shaped or oval nuclei, evenly distributed chromatin, and long fibrillary cytoplasmic processes forming bipolar and stellate configurations.
Strong, Diffuse S100 Expression Dermal nerve sheath myxomas are strongly S100(+) consonant with Schwann cell differentiation. This immunohistochemically stained section depicts diffuse and intense nuclear and cytoplasmic reactivity.
forming bipolar and stellate configurations.
and cytoplasmic 
reactivity.
