Deep Benign Fibrous Histiocytoma



Deep Benign Fibrous Histiocytoma


Elizabeth A. Montgomery, MD





Key Facts


Clinical Issues



  • Painless mass of subcutaneous tissue


  • Most common location is lower extremity


  • Local recurrences common (about 20%)


  • Rare metastases and rarer tumor-associated deaths


Macroscopic Features



  • Well marginated with yellow-tan firm cut surface


Microscopic Pathology



  • Well marginated, sometimes with pseudocapsule (except where tumor extends into cutis; collagen trapping)


  • Storiform pattern


  • Bland nuclei, vesicular chromatin, delicate nucleoli


  • Variable lymphocytes, plasma cells, foam cells, osteoclast-like giant cells






Low magnification shows a deep benign fibrous histiocytoma (BFH). The lesion is in subcutaneous fat image and has a pseudocapsule (in contrast to cutaneous BFH), with a slightly infiltrative border.






This deep fibrous histiocytoma displays a prominent storiform pattern and hemosiderin deposition image. The individual cells are plump with round nuclei.


TERMINOLOGY


Abbreviations



  • Deep benign fibrous histiocytoma (BFH)


Synonyms



  • Deep dermatofibroma


CLINICAL ISSUES


Epidemiology



  • Incidence o Rare


  • Age



    • Median: ≈ 40 years


  • Gender



    • Slight male predominance


Presentation

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Jul 9, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Deep Benign Fibrous Histiocytoma

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