Cutaneous Myxoma and Angiomyxoma

Steven D. Billings, MD

Key Facts

Etiology/Pathogenesis

May be associated with Carney complex (also known as NAME and LAMB syndromes)
- If patient has multiple cutaneous myxomas, consider the possibility of Carney complex

Microscopic Pathology

Relatively hypocellular proliferation of bland spindled to stellate fibroblasts
Abundant myxoid stroma
Thin-walled blood vessels
Perivascular neutrophils common
May have associated epithelial proliferation, usually resulting from entrapped adnexal structures

Top Differential Diagnoses

Cutaneous myxomas are dermal-based tumors characterized by a hypocellular proliferation of bland spindled cells and abundant myxoid stroma.

Intermediate magnification shows that the spindled cells are associated with a capillary vasculature

. Often there are subtly more cellular

and less cellular

areas.

TERMINOLOGY

Synonyms

Definitions

Benign mesenchymal proliferation of spindled to stellate fibroblasts in abundant myxoid stroma

ETIOLOGY/PATHOGENESIS

Some Cases Associated with Carney Complex

Jul 8, 2016 | Posted by drzezo in PATHOLOGY & LABORATORY MEDICINE | Comments Off

Basicmedical Key