Chondroid Lipoma
Khin Thway, BSc, MBBS, FRCPath
Key Facts
Terminology
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Uncommon benign neoplasm with features of embryonal fat and embryonal cartilage
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Balanced translocation t(11;16)(q13; p12-13) in some cases; thought to be specific for lesion
Clinical Issues
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Peak incidence in 3rd and 4th decades
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Female preponderance
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Occurs in superficial and deep locations
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Most frequently affects proximal limbs and limb girdles
Microscopic Pathology
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Nests and cords of rounded cells with granular eosinophilic cytoplasm or multivacuolated cytoplasm containing lipid
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Prominent myxohyaline stroma
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Variable amount of mature adipose tissue
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S100 protein and CD68 positive
Gross photograph of chondroid lipoma shows a circumscribed lesion with a multilobulated, yellow to tan cut surface and prominent hemorrhage. |
Chondroid lipoma shows islands of rounded cells in a hypocellular chondroid-like stroma. The cells are lipoblastic-like, with multivacuolated, lipid-containing cytoplasm  . Mature adipocytes are present. |
TERMINOLOGY
Definitions
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Uncommon benign neoplasm with features of embryonal fat and embryonal cartilage
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Most frequently affects proximal limbs and limb girdles of adult women
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Often mistaken for sarcomas
ETIOLOGY/PATHOGENESIS
Developmental Anomaly
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Etiology unknown
CLINICAL ISSUES
Epidemiology
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Age
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Adults, peak incidence in 3rd and 4th decades
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Gender
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M:F = 1:4
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Site
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Predominantly proximal limbs and limb girdles
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Trunk, head and neck (especially oral cavity)
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Both superficial (subcutaneous) and deep locations
Presentation
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Painless mass
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Recent enlargement in 1/2 of cases
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