Cellular Angiofibroma
Elizabeth A. Montgomery, MD
Key Facts
Terminology
Synonym: Angiomyofibroblastoma-like tumor of male genital tract
Clinical Issues
Middle-aged patients
More common in women
Subcutaneous; usually in vulva or inguinoscrotal region
Benign lesions
Recurrences rare
Examples with sarcomatous features have exhibited benign behavior
Microscopic Pathology
Uniform spindle cells
Fibrous stroma with wispy collagen
Highly vascular
Hyalinized vessels common and characteristic
About 10% contain abundant fat
 At low magnification, this cellular angiofibroma is well marginated but unencapsulated. Note the prominent vessels, readily apparent even at scanning magnification. |
 Thick hyalinized vessels are characteristic of cellular angiofibroma. The lesion is moderately cellular and consists of a uniform population of spindle cells and background collagen fibrils. |
TERMINOLOGY
Synonyms
Angiomyofibroblastoma-like tumor of male genital tract
Definitions
Well-marginated tumor of genital stroma composed of uniform population of bland spindle-shaped cells, wispy collagen, and thick-walled hyalinized vessels
Resembles spindle cell lipoma with 13q- and RB/13q14 allelic loss in some cases
CLINICAL ISSUES
Epidemiology
Incidence o Rare
Age
Middle-aged patients
Gender
More common in women
Presentation
Females
Usually in vulva, occasionally in vagina
Males
Inguinoscrotal region
