Fig. 1 The overlap of brain activations induced by histamine itch (in green) and by cowhage itch (in blue) illustrates the regions coactivated (in red) and distinct areas activated separately…

Category Diseases in dogs I. Dermatological Arising from “diseases of the skin”: e.g., ectoparasites (e.g., scabies, fleas, etc.), allergies (e.g., atopic dermatitis, urticaria, flea allergy dermatitis, etc.), infections (staphylococcal folliculitis,…

Receptor Role in itch Other uses H1 Mediates itch in urticaria, allergic rhinitis, and allergic conjunctivitis The treatment of hives, overall allergic symptoms in rhinitis and conjunctivitis, insomnia H2 No…

TLR Subcellular localization Exogenous ligands Origin of exogenous ligand Endogenous ligands TLR1/TLR2 Cell surface Triacyl lipopeptides Bacteria, viruses Unknown (Pam3CSK4) TLR2/TLR6 Cell surface Diacyl lipopeptides PGN Bacteria, viruses HSP-60, HSP-70,…

Fig. 1 Lack of corresponding functionally defined C-fiber classes in primates and molecular markers in rodents. Only for the markers of Mas-related G-protein-coupled receptor B4 (MrgprB4) and vesicular glutamate transporter…

Fig. 1 TRP channels expressed on the peripheral terminals of sensory neurons as molecular targets for itch- and pain-producing agents. Please note that TRPV1 is a direct downstream target for…

Fig. 1 Structure of natriuretic peptides. A comparison of the primary structure (table) of mouse, human, and rat natriuretic polypeptides reveals that Nppa displays greater sequence conservation than Nppb. Despite…

Fig. 1 Schematic representation of desirable sites of action of antipruritic agents. Since vigorous scratching worsens skin conditions, suppression of both itching and scratching is important in the treatment of…

Fig. 1 Venn diagram summarizing the expression of Mrgprs in DRG neurons. The small- to medium-diameter neurons represent the major primary sensory neuron population in the DRG and can be…