High-Grade Serous Adenocarcinoma Martin Köbel, MD Blake C. Gilks, MD, FRCPC Key Facts Clinical Issues Bilateral (60%) Mean: 6th to 7th decade Stage dependent; 30-40% overall 5-year survival Macroscopic Features…

Low-Grade Serous Adenocarcinoma Martin Köbel, MD Esther Oliva, MD Key Facts Etiology/Pathogenesis Association with serous borderline tumor KRAS, BRAF, NRAS mutations (MAPK pathway alterations) Clinical Issues Usually high stage Low…

Endocervical Glandular Hyperplasia (Diffuse and Lobular) Marisa R. Nucci, MD Key Facts Clinical Issues Typically incidental finding Excellent prognosis If atypical features present in LEGH, may be associated with adenoma…

Tunnel Clusters Brooke E. Howitt, MD Marisa R. Nucci, MD Key Facts Clinical Issues 8% of all adult women Typically asymptomatic Incidental finding at hysterectomy or cone biopsy Benign Microscopic…

Arias-Stella Reaction Marisa R. Nucci, MD Key Facts Terminology Altered cellular and nuclear change of epithelium most commonly associated with pregnancy Clinical Issues May occur anywhere in female genital tract…

Malignant Melanoma, Vagina C. Blake Gilks, MD, FRCPC Key Facts Clinical Issues < 3% of malignant tumors of vagina Peri- and postmenopausal ages (mean: 57 years) Distal 1/3 (anterior) of…

Yolk Sac Tumor, Vagina C. Blake Gilks, MD, FRCPC Esther Oliva, MD Key Facts Clinical Issues Children < 3 years Painless vaginal mass, may prolapse through introitus Combination chemotherapy associated…

Vaginal Intraepithelial Neoplasia C. Blake Gilks, MD, FRCPC Key Facts Clinical Issues More common > 40 years (peak: 60-70) Frequent history of HPV-associated CIN, VIN, or cervical or vulvar squamous…

Ligneous Vaginitis Marisa R. Nucci, MD Key Facts Etiology/Pathogenesis Inherited type I plasminogen deficiency Clinical Issues Degree and extent of associated clinical symptoms and signs not predictable Microscopic Pathology Subepithelial…

Desquamative Inflammatory Vaginitis Marisa R. Nucci, MD Key Facts Terminology Inflammatory vaginitis with marked inflammation and sloughing of epithelium Etiology/Pathogenesis Unknown, may be autoimmune or may represent form of erosive…