Kidney Needle Biopsy: Evaluation for Adequacy
Kidney Needle Biopsy: Evaluation for Adequacy Renal 16-g cores are typically 1 mm in diameter × 10-20 mm long (these are ˜ 13 mm). Glomeruli are pale or congested bulges;…
PATHOLOGY & LABORATORY MEDICINE
Colon: Diagnosis and Margins
Colon: Diagnosis and Margins This invasive colon carcinoma is located far from the proximal and distal margins . Frozen section is unnecessary if the mucosa at the resection margins appears…
Kidney: Evaluation of Allograft Prior to Transplantation
Kidney: Evaluation of Allograft Prior to Transplantation This donor kidney biopsy appears edematous and the glomeruli appear hypercellular , common artifacts of frozen sections. The percentage of globally sclerotic glomeruli…
Colon: Evaluation for Hirschsprung Disease
Colon: Evaluation for Hirschsprung Disease In the normal colon, the myenteric plexus reveals typical ganglion cells with large eccentric nuclei, prominent nucleoli, and abundant eosinophilic cytoplasm . In HD, ganglion…
Larynx: Diagnosis and Margins
Larynx: Diagnosis and Margins Invasive keratinizing squamous cell carcinoma is characterized by irregular nests of atypical squamous epithelium, with focal areas of keratinization, eliciting a loose desmoplastic stromal response. Verrucous…
Specimen Handling, Whipple
Specimen Handling, Whipple Laura Webb Lamps, MD Grace E. Kim, MD This illustration shows the Whipple (pancreaticoduodenectomy) procedure. Note the common bile duct margin , the pancreatic margin , and…
Antibody Index
Antibody Index Antibodies Discussed Antibody Name/Symbol Antibody Description Clones/Alternative Names α-1-antitrypsin alpha-1-antitrypsin A1AT α-fetoprotein alpha 1 fetoprotein AFP, Z5A06, clone C3 β-catenin beta catenin; involved in regulation of cell adhesion…
Ampulla of Vater Cancer Protocol
Ampulla of Vater Cancer Protocol Laura Webb Lamps, MD Ampulla of Vater: Ampullectomy, Pancreaticoduodenectomy (Whipple Resection) Surgical Pathology Cancer Case Summary (Checklist) Specimen (select all that apply) ____ Ampulla of…
Paraganglioma
Paraganglioma Mari Mino-Kenudson, MD Key Facts Terminology Gangliocytic paraganglioma Uncommon (approximately 1% of ampullary neoplasms) Some cases associated with NF-1 Clinical Issues Most commonly involve periampullary duodenum Clinically benign Microscopic…
Poorly Differentiated Neuroendocrine Carcinoma, Ampulla
Poorly Differentiated Neuroendocrine Carcinoma, Ampulla Vikram Dishpande, MD Key Facts Clinical Issues Aggressive tumors with mean survival of 14.5 months Microscopic Pathology Tumors resemble either small cell carcinoma or large…
