Cerebral Hemispheres: Diagnosis Glioblastoma is the most common and most aggressive brain tumor, illustrated here as a large mass with a hemorrhagic and necrotic center and extending across the corpus…

Lung: Nonneoplastic Diffuse Disease: Diagnosis Tissue procured to diagnose nonneoplastic lung disease is generally taken as a wedge-shaped fragment from the periphery of 1 or multiple lobes. Staples in the…

Bone Lesion/Tumor: Diagnosis and Margins The morphology of metastatic carcinoma varies widely depending on the type of primary tumor and degree of differentiation. This metastatic adenocarcinoma displays well-formed glandular elements…

Esophagus: Diagnosis and Margins The most common esophageal tumor is adenocarcinoma arising near the gastroesophageal (GE) junction. The proximal margin is is covered by squamous mucosa and the distal margin…

Lung: Margins The bronchial margin may be identified as 1 or 2 small firm-walled tube(s) . At times, the surgeon may mark the margin with a stitch. The site is…

Fallopian Tube: Diagnosis An ectopic pregnancy can be a medical emergency and is identified by immature placental villi and implantation site within a fallopian tube. Fimbriae underlie the implantation site….

Liver, Intrahepatic Mass: Diagnosis and Margins Oligometastatic colon carcinoma or neuroendocrine tumors to the liver may undergo resection. Surgeons often request intraoperative evaluation of the hepatic margin to ensure complete…

Cerebellum and Brainstem: Diagnosis Glial tumors are the most common primary tumor of the cerebellum and brainstem. This diffuse pontine glioma compresses the 4th ventricle and surrounds the basilar artery…

Adrenal and Paraganglia: Diagnosis The most common tumor of the adrenal is a benign adenoma arising from the cortex. Many are yellow-orange in color, as is the cortex, due to…

Lymph Nodes Below Diaphragm: Diagnosis Metastatic carcinomas should closely resemble the primary carcinoma. This abdominal lymph node shows both metastatic well-differentiated colon carcinoma and prostate carcinoma . Benign inclusions should…