Cutaneous Involvement in Systemic Diffuse Large B-Cell Lymphomas Alejandro A. Gru DEFINITION The overall landscape of systemic B-cell lymphomas with a large-cell component has undergone major changes in the most…
Intravascular Large B-Cell Lymphoma Alejandro A. Gru DEFINITION Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of extranodal large B-cell lymphoma characterized by the confinement of lymphoma cells within…
Systemic Follicular Lymphoma, Marginal Zone Lymphomas, and Waldenström Macroglobulinemia Alejandro A. Gru FOLLICULAR LYMPHOMA Definition Systemic follicular lymphoma (sFL) is the most common subtype of non-Hodgkin lymphomas (NHL), accounting for…
Lymphomatoid Granulomatosis Alejandro A. Gru DEFINITION Lymphomatoid granulomatosis (LyG) is a rare angiocentric and angiodestructive Epstein–Barr virus (EBV)-associated B-cell lymphoproliferative disorder (LPD) with a predilection for the lung, central nervous…
Cutaneous Diffuse Large B-Cell Lymphomas Alejandro A. Gru DEFINITION The WHO defines diffuse large B-cell lymphoma, leg type (DLBCL-LT), as a malignant neoplasm of intermediate aggressive behavior, occurring most frequently…
Primary Cutaneous Marginal Zone B-Cell Lymphoma Katalin Ferenczi DEFINITION Primary cutaneous marginal zone B-cell lymphomas (PCMZLs) are indolent low-grade B-cell lymphomas of the skin. PCMZLs have been regarded as the…
Primary Cutaneous Follicle-Center B-Cell Lymphoma Michi M. Shinohara DEFINITION Primary cutaneous follicle-center B-cell lymphoma (PCFCL) is a neoplastic proliferation of germinal center B cells in the skin. PCFCL is one…
Approach to the Diagnosis of Cutaneous B-Cell Lymphomas Alejandro A. Gru Elaine S. Jaffe INTRODUCTION The diagnosis of cutaneous B-cell lymphomas (CBCLs) requires a careful evaluation of the clinical features,…
NK-Cell Leukemias/Lymphomas Youssef Youssef Alejandro A. Gru Aharon G. Freud INTRODUCTION Natural killer (NK) cells comprise a third major lineage of lymphocytes that are distinct from B cells and T…
Adult T-Cell Leukemia/Lymphoma Melissa Pulitzer DEFINITION Adult T-cell leukemia/lymphoma (ATLL) is an aggressive peripheral T-cell malignancy of a mature helper-T/regulatory-phenotype, which develops after chronic infection with human T-lymphotropic virus 1…
