Granuloma Annulare–Like Reactions Karolyn A. Wanat Misha Rosenbach INTRODUCTION Cutaneous granulomatous inflammation has been reported in association with underlying lymphoproliferative disorders in primarily two patterns: granulomas within or surrounding the…
Cryoglobulinemia Alejandro A. Gru DEFINITION Cryoglobulins are abnormal serum immunoglobulins that reversibly precipitate at low temperature. Two forms of cryoglobulinemias are distinguished based on the composition of the cryoglobulins and…
Paraneoplastic Pemphigus Milda Chmieliauskaite Faizan Alawi INTRODUCTION Paraneoplastic pemphigus (PNP) is an autoimmune vesiculobullous disorder.1 PNP was first described in 1990 as a distinct clinical entity different from pemphigus vulgaris…
Vasculitis Alejandro A. Gru INTRODUCTION Vasculitis refers to a heterogeneous group of disorders characterized by vessel inflammation.1 The clinical manifestations range from locoregional ischemic and purpuric injuries to systemic disease….
Wells Syndrome (Eosinophilic Cellulitis) Melinda Jen Adam I. Rubin INTRODUCTION First described in 1971 by George Wells, Wells syndrome (or eosinophilic cellulitis) is an uncommon, recurrent inflammatory dermatosis of unknown…
Sweet and Histiocytoid Sweet Syndrome Viktoryia Kazlouskaya Jacqueline M. Junkins-Hopkins DEFINITION Sweet syndrome (SS), also known as acute neutrophilic dermatosis, is a predominantly neutrophilic disorder, frequently associated with systemic involvement….
Eosinophilic Dermatosis of Hematologic Malignancy Joya Sahu Jason B. Lee Eosinophilic dermatosis may be encountered in the setting of various hematologic malignancies and hematologic disorders, including blood dyscrasias and myelodysplastic…
Blastic Plasmacytoid Dendritic Cell Neoplasm M. Yadira Hurley Stephen P. Olsen DEFINITION Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a unique myeloid precursor neoplasm that primarily manifests first with cutaneous…
Cutaneous Extramedullary Hematopoiesis András Schaffer DEFINITION Two categories of extramedullary hematopoiesis (EMH) can be distinguished on the basis of pathogenesis, clinical presentation, and histopathology. In the first category, EMH is…
Cutaneous Manifestations of Myeloproliferative Neoplasms Richard Danialan Carlos A. Torres-Cabala INTRODUCTION Myeloproliferative neoplasms (MPNs) are a group of hematopoietic disorders characterized by the clonal proliferation of cells in the myeloid…
