Contusions Abida K. Haque Pulmonary contusions can occur as a result of rapid deceleration injury, explosions, or high-velocity projectile injury to the chest or abdomen. Often, there is no obvious…

Fires and Smoke Inhalation Abida K. Haque Respiratory complications are a major cause of death in victims of fire and inhalation injury. The presence of inhalation injury dramatically increases mortality,…

Drowning Abida K. Haque Drowning is a common cause of accidental deaths, particularly in children. The lungs are edematous in both fresh and saltwater drowning; however, “dry lungs,” or absence…

Radiation Pneumonitis Hakan Çermik Mary L. Ostrowski Roberto Barrios Radiation-induced lung injury—acute, delayed, or chronic—is damage to the lung produced by ionizing radiation. Pathologic changes in radiated fields may follow…

Other Drugs Roberto Barrios Alvaro C. Laga Mary L. Ostrowski Carlos Bedrossian Hakan Çermik Other drugs that may induce pulmonary toxicity include cyclophosphamide, bleomycin, busulphan, sulfasalazine, and nitrofurantoin. Cyclophosphamide pulmonary…

Gefitinib Timothy C. Allen Gefitinib, an oral selective inhibitor of epidermal growth factor receptor tyrosine kinase, is a new molecular-targeted agent used for the treatment of patients with advanced non-small-cell…

Phen-fen Roberto Barrios Timothy C. Allen Phen-fen, a combination of the amphetamine analogs phentermine and fenfluramine, has been used to treat obesity and substance-abuse disorders. Primary pulmonary hypertension has been…

Methotrexate Roberto Barrios Hakan Çermik Methotrexate is a folic acid antagonist that has been used as an antineoplastic and antiinflam-matory drug. Methotrexate pneumonitis is an unpredictable and sometimes life-threatening side…

Lung Pathology in Collagen Vascular Diseases Abida K. Haque Collagen vascular diseases are a group of immunologically mediated diseases, and may be associated with both localized and diffuse pulmonary lesions….

Amiodarone Roberto Barrios Hakan Çermik’s Amiodarone is a frequently used antiarrhythmic drug. It causes lung changes that are largely reversible but which may become permanent over time. Cytologic Features Finely…