Vaccinia Lymphadenitis Definition Lymphadenitis caused by infection with vaccinia virus. Synonyms Postvaccinial lymphadenitis, smallpox vaccination adenitis. Etiology Vaccinia virus infections usually do not occur naturally, being generally induced as vaccination…
Varicella-Herpes Zoster Lymphadenitis Definition Lymphadenitis caused by infection with varicella or herpes zoster virus. Etiology The viruses isolated from patients with varicella (chickenpox) or herpes zoster (shingles) are physically and…
Herpes Simplex Virus Lymphadenitis Definition Lymphadenitis caused by infection by herpes simplex virus (HSV). Synonym HSV lymphadenitis. Clinical Syndrome Herpes simplex virus has a worldwide distribution and is primarily spread…
Infectious Mononucleosis Lymphadenitis Definition Acute lymphadenitis caused by infection with Epstein-Barr virus (EBV). Synonym EBV lymphadenitis; infectious mononucleosis. Etiology The human herpesvirus family, the Herpesviridae, includes 25 families of viruses…
Cytomegalovirus Lymphadenitis Definition Lymphadenitis caused by infection with cytomegalovirus (CMV). Synonym CMV lymphadenitis. Epidemiology Cytomegalovirus is a ubiquitous pathogenic agent with worldwide distribution. In the United States, complement-fixing antibodies to…
Introduction A variety of viruses can cause acute or chronic lymphadenitis. In some cases, the presence of viruses in the affected lymph nodes can be demonstrated by histologic, immunologic, molecular,…
Introduction Lymphadenitides are acute and chronic inflammatory processes of lymph nodes that occur in response to a variety of pathogenic agents. They may be specific or nonspecific, featuring necrosis, abscesses,…
Molecular Diagnosis New insights during the last two decades have catapulted genetic studies of malignant lymphomas from a research tool to a routine laboratory test. Unlike immunophenotypic studies using flow…
Flow Cytometry As discussed in Chapter 6, immunophenotyping is a key component of the World Health Organization (WHO) lymphoma classification and is necessary for the diagnosis of most specific lymphoma…
Immunohistochemistry Immunophenotypic analysis is extremely helpful and often essential for the diagnosis and classification of malignant neoplasms. Two major methods are used for determining the immunophenotype of neoplasms: immunohistochemistry and…
