Drug-induced Lymphadenopathy Definition Lymphadenopathy that can mimic malignant lymphoma associated with drug therapy, usually as a result of a hypersensitivity reaction. A wide variety of drugs can induce lymphadenopathy (Table…
Castleman Lymphadenopathy Definition In the original reports by Castleman et al. (1,2), Castleman disease (CD) was described as a large, benign, asymptomatic mass involving mediastinal lymph nodes. Fifty years later,…
Introduction A variety of vascular disorders may affect the lymph nodes, resulting in ischemic infarction, benign vascular prolife-rations, or malignant vascular neoplasms. Lymph nodes are well vascularized, and therefore ischemic…
Drug-Induced Lymphadenopathy: Methotrexate Definition Lymphoproliferative disorders associated with methotrexate therapy, usually administered to patients with connective tissue diseases. Introduction Patients with immunodeficiency have an increased risk of lymphoproliferative disorders, in…
Tumor-Reactive Lymphadenopathy Definition Reactive, usually enlarged, regional lymph nodes draining tumor areas. Pathogenesis Regional lymph nodes tributary to tumor-bearing organs are considered anatomic barriers to tumor spread. They are also…
Introduction Lymphadenopathies may occur in patients treated with a variety of immunomodulatory drugs. Drugs such as prednisone, azathioprine, methotrexate, cyclosporine, and others are used to diminish the symptoms of hyperimmune…
Lymphadenopathies of Salivary Glands Definition Lymphadenitides and lymphadenopathies of salivary glands, lymphoid characterized by lymphoepithelial lesions (LEL). Pathogenesis Normally, lymphoid tissues are intimately associated with salivary glands in various forms…
Dermatopathic Lymphadenopathy Definition Reactive paracortical hyperplasia of lymph node characterized by an increased number of interdigitating dendritic cells, Langerhans cells, and histiocytes with cytoplasmic melanin deposits and lipid vacuoles. These…
Rheumatoid Lymphadenopathy Definition Lymphadenopathy accompanying rheumatoid arthritis (RA). Epidemiology Rheumatoid arthritis is common disease, affecting 0.8% of the world’s population (1). Approximately 2 million people in the United States have…
Sarcoidosis Lymphadenopathy Definition Sarcoidosis is a multisystem granulomatous disease of worldwide distribution and unknown cause. Epidemiology Sarcoidosis occurs worldwide, affecting persons of all races and ages. A seasonal clustering prevails,…
