Acknowledgments The author would like to thank Michael Arends for his assistance with manuscript preparation. Definitions Relevant to Animal Models Drug addiction, also known as substance use disorder, is a…
Key wordsCocaine use disorder, cocaine-induced anxiety disorder, cocaine-induced mood disorder, cocaine-induced psychotic disorder, cocaine-induced sexual dysfunction, cocaine-induced sleep disorder, craving and relapse, intoxication, intoxication delirium, withdrawal Introduction The effects…
Acknowledgments We thank the National Institute on Alcohol Abuse and Alcoholism for its support through the Neurobiology of Adolescent Drinking in Adulthood (NADIA) consortium (AA020024, AA020023), the Bowles Center for…
Acknowledgments We thank Catharine Helms and Robert H. Cormier, Jr., for their assistance with manuscript preparation. Introduction Alcohol is one of the oldest and the most widely used psychoactive substances…
Acknowledgment The writing of this chapter was supported in part by funding of the following NIH grants: DA012498, DA003628, and DA06634 (SEH). Introduction The comprehensive sequencing of human and other…
Ethanol (Alcohol) History Ethanol is surely the oldest known substance of abuse. The details of the original discovery of fermented beverages have been lost to time because of the unavailability…
Introduction Drug use disorders involve a number of factors including genetic and environmentally influenced predispositions, the actions of the drugs themselves, the immediate environment, and the neurobiological mechanisms that promote…
What Is Metabolomics? Metabolomics is the newest addition to the “omics” science. An “omics” has been defined as a neologism referring to a holistic view on biologic macromolecules, such as…
Introduction A comprehensive understanding of the underlying neurobiology of alcohol and other drug use will likely prove essential in developing more effective prevention, early intervention, and treatment strategies. Ethical limitations…
Introduction Addictions are a constellation of complex and chronic illnesses that affect multiple domains in a patient’s life, primarily for the worst. Nosologically, they are defined by use of an…
