The lymphatics are an extensive unidirectional system of blunt-ending vessels that regulate normal tissue pressure by retrieving excess fluid from the interstitium, transporting it to regional lymph nodes, and returning…
This chapter discusses a heterogeneous group of benign tumors or pseudotumors, many of which are characterized by abundant myxoid stroma (intramuscular myxoma, juxta-articular myxoma, cutaneous myxoma, ganglion). Evidence indicates that…
The synovial membrane forms the lining of joints, tendons, and bursae. In addition, its cells synthesize hyaluronate, a major component of synovial fluid, and facilitate the exchange of substances between…
The significance and multiple functions of fat are not always fully appreciated. Fat serves not only as one of the principal and most readily available sources of energy in the…
Angiosarcoma Angiosarcomas are malignant tumors that recapitulate many of the functional and morphologic features of normal endothelium. They vary from highly differentiated tumors resembling a hemangioma to anaplastic lesions difficult…
To a large extent, the distribution of benign smooth muscle tumors parallels the distribution of smooth muscle tissue in the body. The tumors tend to be relatively common in the…
Originally viewed as smooth muscle tumors (leiomyoblastomas), it is now known that gastrointestinal stromal tumors ( GISTs ) arise from interstitial cells of Cajal (ICCs) or ICC precursor cells. ICCs…
The concept of fibrohistiocytic neoplasms has been challenged largely because the malignant forms (i.e., malignant fibrous histiocytoma) consistently lack histiocytic features, and because some, when carefully studied, show a subtle…
Although previously grouped together in this textbook, superficial and deep fibromatoses are now discussed separately because of distinct differences in clinical behavior. The superficial fibromatoses are described with the benign…
Leiomyosarcomas account for 5% to 10% of soft tissue sarcomas. They are principally tumors of adults but are far outnumbered even in this age group by more common sarcomas, such…
