Soft Tissue Tumors All categories of soft tissue tumors have been reported to involve the upper aerodigestive tract. These include neoplasms that show fibroblastic, myofibroblastic, vascular, myogenous, and neural differentiation….

Pathology of the Ear Like the sinonasal tract, the ear has a rather complicated anatomy with multiple types of epithelium, adnexa, and close proximity to disparate structures. The different portions…

Nonneoplastic Lesions of the Nasal Cavity, Paranasal Sinuses, and Nasopharynx Most samples from the nasal cavity, paranasal sinuses, and nasopharynx are for nonneoplastic disease. Perhaps because they are so often…

Nonneoplastic Lesions of the Oral Cavity A vast array of nonneoplastic lesions arise in the mouth including traumatic, infectious, inflammatory, and autoimmune processes, among others. Given its location and its…

Nonneoplastic Lesions of the Larynx The larynx is most often biopsied because of suspicion of malignancy. Many biopsies will be diagnosed as conventional squamous cell carcinomas; however, nonneoplastic pathologies can…

Bone, Cartilaginous, and Jaw Lesions That May Be Sampled with Upper Aerodigestive Tract Biopsies Numerous bony, cartilaginous, and odontogenic lesions can involve the upper aerodigestive tract. Some can involve all…

Hematopoietic and Lymphoid Disorders Abundant mucosa-associated lymphoid tissue is present within the upper aerodigestive tract that can be involved by both nonneoplastic proliferations and malignancies.1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25 The remaining tract may be…

Neural, Neuroectodermal, and Neuroendocrine Neoplasms A variety of neural, neuroectodermal, and neuroendocrine neoplasms can occur throughout the region of the upper aerodigestive tract. These lesions may show overlapping histologic features…

Germ Cell Tumors It is extremely uncommon for extragonadal germ cell tumors to involve the head and neck and even more uncommon for them to actually arise from the upper…