In the ensuing chapter, the cellular lineage markers and the application of immunohistochemistry (IHC) in the diagnosis and management of specific tumor types are reviewed. We feel obliged to provide…
Overview Pathologists frequently use immunohistochemistry (IHC) to evaluate antigen location and expression patterns in tissue for diagnostic and/or prognostic purposes. This process often also requires quantification of these immunostains to…
This chapter divides the discussion of immunohistochemistry (IHC) of the luminal gastrointestinal (GI) tract into three sections: (1) epithelial pathology, (2) neuroendocrine lesions, and (3) spindle cell lesions. We have…
Chapter Outline Overview, 588 Biology of Antigens and Antibodies, 588 Diagnostic Immunohistochemistry of Specific Prostate Lesions, 591 Beyond Immunohistochemistry: Theranostic and Genomic Applications, 608 Summary, 623 Overview Used in the…
Overview The unprecedented advances in cancer genetics and genomics are rapidly affecting the clinical management of solid tumors. Molecular diagnostics are now an integral part of routine clinical management for…
Overview The skin is a complex microenvironment. The normal structures of the epidermis, dermis, and cutaneous adnexa are morphologically and functionally complicated, and the histologic entities that occur in this…
Only a little more than 30 years ago a popular, widely used classification system for non-Hodgkin lymphomas was initiated based solely on hematoxylin and eosin (H&E)–stained slide interpretation. The “Working…
The impact of diagnostic immunohistochemistry (IHC) for the surgical pathologist is legendary, and it is best appreciated when studying malignancies of unknown primary site. A cost-effective tool, IHC is performed…
Overview Melanoma continues to represent one of the greatest diagnostic challenges in surgical pathology and is an important source of litigation. Both as a primary lesion in the skin and…
During the last 2 decades, the approach to histopathologic diagnosis has been dramatically transformed by immunohistochemistry (IHC), specifically in the diagnosis and classification of tumors, and more recently in the…
