Carcinoid Tumor



Carcinoid Tumor


Steven S. Shen, MD, PhD

Jae Y. Ro, MD, PhD










Testicular carcinoid tumor image shows a well-circumscribed nodule demarcated from the adjacent seminiferous tubules image. The tumor has nested, trabecular, and insular growth patterns.






High-power view shows a carcinoid tumor with relatively uniform cells, round to ovoid nuclei, “salt and pepper” chromatin, and abundant eosinophilic and granular cytoplasm.


TERMINOLOGY


Synonyms



  • Well-differentiated neuroendocrine carcinoma


Definitions



  • Well-differentiated tumor with neuroendocrine differentiation, which may occur as pure tumor, as component associated with teratoma or metastatic to testis


ETIOLOGY/PATHOGENESIS


Pathogenesis



  • Considered to be a monodermal form of teratoma


CLINICAL ISSUES


Epidemiology



  • Incidence



    • Extremely rare


    • Majority (70%) are pure carcinoid &/or associated with a teratoma (20%)


    • Rare cases of metastatic carcinoid (10%) from lung or gastrointestinal tract have been reported


  • Age



    • Range 10-83 years (average: 46 years); primary carcinoid: 44 years; metastasis: 61 years; carcinoid within teratoma: 38 years


    • In general, occurs in older age group than most other types of germ cell tumor


Presentation



  • Testicular enlargement ± pain


  • Equally distributed in left and right sides


  • May be associated with hydrocele (10%)


  • Carcinoid syndrome may occur (12%)

Jul 7, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Carcinoid Tumor
Premium Wordpress Themes by UFO Themes
%d bloggers like this: