Benign Metastasizing Leiomyoma
Elizabeth A. Montgomery, MD
Key Facts
Terminology
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Rare lesion usually typified by multiple benignappearing smooth muscle neoplasms of lung in women with coexisting or past uterine leiomyoma
Clinical Issues
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Rare
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Late reproductive years
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Exclusively female
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Surgical excision of metastases
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Hormonal manipulation
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Overall good
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Reports of deaths from respiratory failure
Microscopic Pathology
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Lung lesions identical to those of uterine leiomyomas
Ancillary Tests
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Smooth muscle antigens positive
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ER(+) and PR(+)
Hematoxylin & eosin show a well-marginated lung nodule detected in a woman with a remote history of a uterine leiomyoma. A vascular wall  can be seen. |
Hematoxylin & eosin shows the margin between this bland smooth muscle lesion and the surrounding lung. A compressed vessel wall surrounds the lesion  . |
TERMINOLOGY
Abbreviations
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Benign metastasizing leiomyoma (BML)
Definitions
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Rare lesion usually typified by multiple benignappearing smooth muscle neoplasms of lung in women with coexisting or past uterine leiomyoma
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Subset associated with intravenous leiomyomatosis
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CLINICAL ISSUES
Epidemiology
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Incidence
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Rare
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Age
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Late reproductive years
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Gender
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Exclusively female
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