Benign Metastasizing Leiomyoma
Elizabeth A. Montgomery, MD
Key Facts
Terminology
Rare lesion usually typified by multiple benignappearing smooth muscle neoplasms of lung in women with coexisting or past uterine leiomyoma
Clinical Issues
Rare
Late reproductive years
Exclusively female
Surgical excision of metastases
Hormonal manipulation
Overall good
Reports of deaths from respiratory failure
Microscopic Pathology
Lung lesions identical to those of uterine leiomyomas
Ancillary Tests
Smooth muscle antigens positive
ER(+) and PR(+)
 Hematoxylin & eosin show a well-marginated lung nodule detected in a woman with a remote history of a uterine leiomyoma. A vascular wall  can be seen. |
 Hematoxylin & eosin shows the margin between this bland smooth muscle lesion and the surrounding lung. A compressed vessel wall surrounds the lesion  . |
TERMINOLOGY
Abbreviations
Benign metastasizing leiomyoma (BML)
Definitions
Rare lesion usually typified by multiple benignappearing smooth muscle neoplasms of lung in women with coexisting or past uterine leiomyoma
Subset associated with intravenous leiomyomatosis
CLINICAL ISSUES
Epidemiology
Incidence
Rare
Age
Late reproductive years
Gender
Exclusively female
