Pityriasis Lichenoides Chronica Emily Y. Chu DEFINITION, CLINICAL PRESENTATION, AND PROGNOSIS Pityriasis lichenoides chronica (PLC) is a benign, self-limited, diffuse skin eruption composed of discrete red–brown scaly papules (Fig. 37-1)….
Cutaneous Involvement by Hodgkin Lymphoma Alejandro A. Gru András Schaffer DEFINITION Hodgkin lymphoma (HL) is a clonal lymphoproliferative disease of germinal center B-cell origin. Lymph nodes of the cervical (75%…
Cutaneous Plasma Cell Neoplasms Liaqat Ali Jozef Malysz INTRODUCTION Plasma cell neoplasms (PCN) include a spectrum of diseases that ranges from clinically indolent entities, such as monoclonal gammopathy of unknown…
Cutaneous Manifestations of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Alejandro A. Gru DEFINITION Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is the most common adult leukemia in Europe and North America, with…
Cutaneous Mantle Cell Lymphoma Alejandro A. Gru DEFINITION Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin lymphoma (NHL) that comprises approximately 3% to 10% of the systemic B-cell NHL.1,2,3,4 It…
Cutaneous Involvement in Systemic Diffuse Large B-Cell Lymphomas Alejandro A. Gru DEFINITION The overall landscape of systemic B-cell lymphomas with a large-cell component has undergone major changes in the most…
Intravascular Large B-Cell Lymphoma Alejandro A. Gru DEFINITION Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of extranodal large B-cell lymphoma characterized by the confinement of lymphoma cells within…
Systemic Follicular Lymphoma, Marginal Zone Lymphomas, and Waldenström Macroglobulinemia Alejandro A. Gru FOLLICULAR LYMPHOMA Definition Systemic follicular lymphoma (sFL) is the most common subtype of non-Hodgkin lymphomas (NHL), accounting for…
Lymphomatoid Granulomatosis Alejandro A. Gru DEFINITION Lymphomatoid granulomatosis (LyG) is a rare angiocentric and angiodestructive Epstein–Barr virus (EBV)-associated B-cell lymphoproliferative disorder (LPD) with a predilection for the lung, central nervous…
Cutaneous Diffuse Large B-Cell Lymphomas Alejandro A. Gru DEFINITION The WHO defines diffuse large B-cell lymphoma, leg type (DLBCL-LT), as a malignant neoplasm of intermediate aggressive behavior, occurring most frequently…
