Overview The unprecedented advances in cancer genetics and genomics are rapidly affecting the clinical management of solid tumors. Molecular diagnostics are now an integral part of routine clinical management for…
Overview The skin is a complex microenvironment. The normal structures of the epidermis, dermis, and cutaneous adnexa are morphologically and functionally complicated, and the histologic entities that occur in this…
Only a little more than 30 years ago a popular, widely used classification system for non-Hodgkin lymphomas was initiated based solely on hematoxylin and eosin (H&E)–stained slide interpretation. The “Working…
The impact of diagnostic immunohistochemistry (IHC) for the surgical pathologist is legendary, and it is best appreciated when studying malignancies of unknown primary site. A cost-effective tool, IHC is performed…
Overview Melanoma continues to represent one of the greatest diagnostic challenges in surgical pathology and is an important source of litigation. Both as a primary lesion in the skin and…
During the last 2 decades, the approach to histopathologic diagnosis has been dramatically transformed by immunohistochemistry (IHC), specifically in the diagnosis and classification of tumors, and more recently in the…
Overview The hematologic system comprises a variety of different tissue and cell types. These include a diverse range of cell functions and organs, including the bone marrow, spleen, and lymph…
Overview Immunohistochemistry (IHC), or immunocytochemistry (ICC), is a laboratory technique used to detect specific antigens (i.e., proteins) in tissues or cells based on antigen-antibody recognition; it seeks to exploit the…
Overview Tumors of soft tissue and bone are a diverse family, and categorization continues to evolve as more insight is gained into their patterns of differentiation and the underlying molecular…
General Principles of Molecular Biology Immunohistochemistry (IHC) is a common technique used for the detection of protein expression in various tissue samples. In modern pathology practice, this methodology is expanded…
