During the last 2 decades, the approach to histopathologic diagnosis has been dramatically transformed by immunohistochemistry (IHC), specifically in the diagnosis and classification of tumors, and more recently in the…
Overview The hematologic system comprises a variety of different tissue and cell types. These include a diverse range of cell functions and organs, including the bone marrow, spleen, and lymph…
Overview Immunohistochemistry (IHC), or immunocytochemistry (ICC), is a laboratory technique used to detect specific antigens (i.e., proteins) in tissues or cells based on antigen-antibody recognition; it seeks to exploit the…
Overview Tumors of soft tissue and bone are a diverse family, and categorization continues to evolve as more insight is gained into their patterns of differentiation and the underlying molecular…
General Principles of Molecular Biology Immunohistochemistry (IHC) is a common technique used for the detection of protein expression in various tissue samples. In modern pathology practice, this methodology is expanded…
Host defense in which T lymphocytes serve as effector cells is called cell-mediated immunity. T cells are essential for eliminating microbes that survive and replicate inside cells and for eradicating…
Humoral immunity is the type of host defense mediated by secreted antibodies that is necessary for protection against extracellular microbes and their toxins. Antibodies prevent infections by blocking microbes from…
Cancer and organ transplantation are two situations in which the immune response to human cells that are genetically distinct from the normal self has important clinical consequences. In order for…
Humoral immunity is mediated by antibodies and is the arm of the adaptive immune response that functions to neutralize and eliminate extracellular microbes and microbial toxins. Humoral immunity is the…
The concept that the immune system is required for defending the host against infections has been emphasized throughout this book. However, immune responses are themselves capable of causing tissue injury…
