Hematopoietic and Lymphoid Disorders Abundant mucosa-associated lymphoid tissue is present within the upper aerodigestive tract that can be involved by both nonneoplastic proliferations and malignancies.1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25 The remaining tract may be…
Neural, Neuroectodermal, and Neuroendocrine Neoplasms A variety of neural, neuroectodermal, and neuroendocrine neoplasms can occur throughout the region of the upper aerodigestive tract. These lesions may show overlapping histologic features…
Germ Cell Tumors It is extremely uncommon for extragonadal germ cell tumors to involve the head and neck and even more uncommon for them to actually arise from the upper…
Salivary Gland-Type Neoplasms Salivary gland-type neoplasms can develop throughout the entire upper aerodigestive tract, likely because seromucinous glands underlie the epithelium throughout these structures. Although these neoplasms occur with different…
Histologic and Etiologic Variants of Squamous Cell Carcinoma Most squamous cell carcinomas (SCCs) of the upper aerodigestive tract are histologically conventional type and as such show, to some degree, a…
Adenocarcinomas, Other Than Those That Can Be Classified As Salivary Gland-Type Most glandular malignancies of the upper aerodigestive tract can best be classified as salivary gland-type malignancies (Table 7.1). A…
Conventional Squamous Cell Carcinoma Conventional squamous cell carcinoma (SCC) is the most common malignant diagnosis made based on biopsy specimens from the upper aerodigestive tract. In fact, it may be…
Precursor Lesions of Squamous Cell Carcinoma Most anatomic pathologists are comfortable with the multihit model for the development of epithelial malignancy. As such, they are accustomed to diagnosing noninvasive premalignant…
Normal Anatomy and Histology The upper aerodigestive tract and ear are unified by location and function. Because this region does not represent a single organ, per se, a discussion of…
Benign Squamous Proliferations and Neoplasms Most neoplasia of the upper aerodigestive tract shows squamous differentiation. Clinically, squamous lesions may be single or multifocal, benign, aggressive, or malignant. Risk factors for…
