Extrinsic Allergic Alveolitis Key Facts Terminology Hypersensitivity pneumonitis (HP) Granulomatous lung disease secondary to inhalation of organic antigens or chemicals Etiology/Pathogenesis History of exposure to organic antigens Saccharopolyspora tectivirgula in…
Hard Metal Pneumoconiosis Pneumonitis Key Facts Terminology Type of pneumonitis caused by exposure to hard metal (cobalt) Etiology/Pathogenesis Exposure to hard metal Hard metal is combination of tungsten with cobalt…
Adenovirus Key Facts Clinical Issues Accounts for about 10% of all pneumonias in children and infants Epidemics have been reported in military personnel Microscopic Pathology 2 major patterns of lung…
Metastatic Malignant Melanoma Key Facts Clinical Issues Lung is frequent site of metastasis for malignant melanoma Middle-aged to elderly patients Image Findings Multiple, well-defined nodules in periphery of lungs Endobronchial…
Allergic Angiitis and Granulomatosis (Churg-Strauss) Key Facts Terminology Systemic process characterized by presence of vasculitis, blood eosinophilia, and asthma Etiology/Pathogenesis No definitive etiology has been defined for Churg-Strauss syndrome Probably…
Erdheim-Chester Disease Key Facts Terminology Rare histiocytic infiltrative disorder that most commonly affects bones but may affect other organs, including lung Clinical Issues Bone involvement is most common site 50%…
Langerhans Cell Histiocytosis Key Facts Terminology Proliferation of Langerhans cells that form multiple interstitial, bilateral, peribronchiolar pulmonary nodules Clinical Issues Highest incidence is in cigarette smokers (95% of patients) 18-40…
Sarcoidosis Key Facts Etiology/Pathogenesis Etiology unknown, but evidence suggests it may represent exaggerated cellular immune response to an unidentified antigen Clinical Issues Most commonly affected sites include lungs (95% of…
Blastomycosis Key Facts Terminology Pulmonary infection caused by inhalation of the fungus Blastomyces dermatidis Clinical Issues Geographic distribution in the USA: Mississippi, Missouri, and Ohio River valleys Acute infection is…
Respiratory Bronchiolitis Key Facts Terminology Respiratory bronchiolitis-interstitial lung disease (RB-ILD) Synonym: Smoker’s bronchiolitis Mild form of interstitial lung disease Etiology/Pathogenesis Closely associated with smoking history Occupational exposure to fumes Clinical…
